Researchers
have developed two inexpensive adapters that enable a smartphone to
capture high-quality images of the front and back of the eye. The
adapters make it easy for anyone with minimal training to take a picture
of the eye and share it securely with other health practitioners or
store it in the patient's electronic record.
Stanford
researchers have developed inexpensive adapters that enable a smartphone
to capture high-quality images of the front and back of the eye.
Researchers
at the Stanford University School of Medicine have developed two
inexpensive adapters that enable a smartphone to capture high-quality
images of the front and back of the eye. The adapters make it easy for
anyone with minimal training to take a picture of the eye and share it
securely with other health practitioners or store it in the patient's
electronic record.
"Think Instagram for the eye," said one of the developers, assistant professor of ophthalmology Robert Chang, MD.
The
researchers see this technology as an opportunity to increase access to
eye-care services as well as to improve the ability to advise on
patient care remotely.
Ophthalmology resident David Myung, MD,
PhD, lead author of two upcoming papers describing the development and
clinical experience with the devices, began the project with Chang about
two years ago, just before Myung began his residency at Stanford. The
papers were published online March 7 in the Journal of Mobile Technology in Medicine.
The
standard equipment used to photograph the eye is expensive -- costing
up to tens of thousands of dollars -- and requires extensive training to
use properly. Primary care physicians and emergency department staff
often lack this equipment, and although it is readily available in
ophthalmologists' offices, it is sparse in rural areas throughout the
world.
Improved care
"Adapting
smartphones for the eye has the potential to revolutionize the delivery
of eye care -- in particular, to provide it in places where it's less
accessible," said Myung. "Whether it's in the emergency department,
where patients often have to wait a long time for a specialist, or
during a primary-care physician visit, this new workflow will improve
the quality of care for our patients, especially in the developing world
where ophthalmologists are few and far between.
"A picture is
truly worth a thousand words," he added. "Imagine a car accident victim
arriving in the emergency department with an eye injury resulting in a
hyphema -- blood inside the front of her eye. Normally the physician
would have to describe this finding in her electronic record with words
alone. Smartphones today not only have the camera resolution to
supplement those words with a high-resolution photo, but also the
data-transfer capability to upload that photo securely to the medical
record in a matter of seconds.
Chang, who is the senior author of
the two papers, added that ophthalmology is a highly image-oriented
field. "With smartphone cameras now everywhere, and a small, inexpensive
attachment that helps the ancillary health-care staff to take a picture
needed for an eye consultation, we should be able to lower the barrier
to tele-ophthalmology," he said.
Adapters are available to attach
a smartphone to a slit lamp -- a microscope with an adjustable,
high-intensity light -- to capture images of the front of the eye. But
Myung found this process time-consuming and inconvenient, even with
commercially available adapters designed for this purpose. Given the
fast pace of patient care, he wanted point-and-shoot ability in seconds,
not minutes, with instant upload to a secure server. More importantly,
the team envisioned the device to be readily usable by any health-care
practitioner, not just eye doctors. So Myung decided to bypass the slit
lamp, a complicated piece of equipment.
"I started entertaining
the idea of a pocket-sized adapter that makes the phone do most of the
heavy lifting," he said. After numerous iterations, he found a
combination of magnification and lighting elements that worked.
Using 'Legos'
"It
took some time to figure out how to mount the lens and lighting
elements to the phone in an efficient yet effective way," said Myung,
who built the prototypes with inexpensive parts purchased almost
exclusively online, including plastic caps, plastic spacers, LEDs,
switches, universal mounts, macrolenses and even a handful of Legos.
After
successfully imaging the front of the eye, he then focused on
visualizing the inside lining of the back of the eye, called the retina.
"Taking a photo of the retina is harder because you need to focus light
through the pupil to reach inside the eye," said Myung.
To
optimize the view through a dilated pupil, Myung used optics theory to
determine the perfect working distance and lighting conditions for a
simple adapter that connects a conventional examination lens to a phone.
Myung and chief ophthalmology resident Lisa He, MD, shot hundreds of
photos with various iterations of the adapter, consulting with Chang and
Mark Blumenkranz, MD, retina specialist and chair of the ophthalmology
department, until they got it right. Then Stanford mechanical
engineering graduate student Alexandre Jais constructed computerized
models of these "screwed-and-glued" prototypes to produce 3D-printed
versions. Jais made the first of these prototypes on his own 3D printer
before moving to the Stanford Product Realization Lab to manufacture
higher-resolution adapters.
Chief resident He is leading a
clinical study grading the quality of images taken using the adapters in
the Stanford emergency department. A second study, spearheaded by
resident Brian Toy, MD, will test the ability of the adapters to track
eye disease in patients with diabetes.
Myung and Chang have
recently been awarded seed grants from the School of Medicine and the
Stanford Biodesign Program to fund the production of the initial batch
of adapters, currently dubbed EyeGo, for distribution and continued
evaluation. The initial adapters will be available for purchase for
research purposes only while the team seeks guidance from the Food and
Drug Administration. "We have gotten the production cost of each type of
adapter to under $90 but the goal is to make it even lower in the
future," Chang said. Recently, a team from the University of Melbourne
in Australia used the two adapters on a medical mission trip to Ethiopia
and told Chang they were excited about the results.
Myung,
Chang, Jais and He co-authored both articles and Blumenkranz co-authored
the article on the retinal-imaging adapter. Stanford's Office of
Technology and Licensing is managing the intellectual property.
Story Source:
The above story is based on materials provided by Stanford University Medical Center. The original article was written by Rosanne Spector. Note: Materials may be edited for content and length.
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